Are Ketogenic Diets Safe?

I’m always surprised when people raise the safety question regarding the ketogenic diet. The ketogenic diet has been used since the 1920’s to treat people who have epilepsy. It is a diet that focuses on healing the brain and eliminating the inflammation that causes seizures. The problem that we have gotten into as a society is that we rely too much on doctors. The “standard of care” for epilepsy now is to try one of the many anticonvulsants on the market today first.

Now, standard of care doesn’t refer to some standard of quality. It refers to the industry standard. Therefore, everyone in the medical industry is following the procedure of trying the latest anticonvulsant for a seizure patient first. This does not mean that the ketogenic diet is harmful. Nor does it mean that it is less effective than the newest anticonvulsant on the markets.[easyazon_image align=”left” cart=”n” height=”500″ identifier=”1524762237″ locale=”US” src=”” tag=”mcurle08-20″ width=”395″]

Generally Regarded As Safe

The items that are on the ketogenic diet can be generally regarded as safe according to the FDA. Eggs, cheese, meat, and low carbohydrate vegetables. Therefore, one would assume that it is safe to be eating ketogenic foods. They are not deemed as harmful and are regarded as safe if you are relying on the FDA’s standard.

However, many things are making the GRAS (generally regarded as safe) definition. Snicker bars, pasta, red dye in M and Ms, McDonald’s, french fries, pizza. All of these things are given approval to be sold in our supermarkets. The FDA doesn’t seem to mind that we eat this stuff, even though it isn’t very nutrient dense. One may wonder, does the FDA really care about my health and well being? Are we sure that they aren’t just a political branch that is bought out by industries for favors. I’ll let you make the decision on that one.

Positive Effect in Obese Patients

While some foods that are generally regarded as safe do create conditions that trigger obesity, the ketogenic diet does not. In fact, current research demonstrates the opposite effect on health. In a study published in Experimental and Clinical Cardiology in 2004, researchers explored the long term effects of a ketogenic diet on obese patients. This study qualified long term as 24 weeks, or six months. The study’s results demonstrated that the ketogenic diet significantly reduced the body weight and body mass index of patients. It also decreased the level of trigylcerides, LDL cholesterol and blood glucose, and increased the level of HDL cholesterol. Therefore, the ketogenic diet had a positive effect on people.

Administering a ketogenic diet for a relatively longer period of time did not produce any significant side effects in the patients. Therefore, the present study confirms that it is safe to use a ketogenic diet for a longer period of time than previously demonstrated. Since this study did not discover any long term negative side effects in patients, this particular study determined that a ketogenic diet is safe.

Reduces Inflammation

When someone starts a ketogenic diet, they are usually coming from a high carbohydrate diet where their bodies focused on glucose metabolism. The ketogenic diet switches them to a fat burning mode. As they burn fats, their bodys begin to produce and metabolize ketones. When you compare ketone metabolism to glucose metabolism, ketone metabolism produces fewer reactive oxygen species, which have been known to have an inflammatory impact on the body. A metabolism based on ketosis produces fewer free radicals and reactive oxygen species by affecting the mitochondrial  co-enzyme Q couple and the cytoplasmic glutathione couple.

When on the ketogenic diet, there is another mechanism which may be assisting in preventing inflammation. There seems to be mounting evidence to show that a ketolytic metabolism increases the levels of the neurotransmitter known as adenosine. Adenosine has been well known to have an anti-inflammatory effect on the body. It acts through recptors at multiple sites including endothelia, neurons and leukocytes. Therefore, the ketogenic diet may create an anti-inflammatory effect  on your body via elevated adenosine levels.

The inflammatory response is influenced by factors that impact the cellular bioenergetic state. These factors include caloric restriction, ketogenic diet and the glycolytic inhibitor 2-deoxyglucose. Caloric restriction and the ketogenic diet produce a ketogenic state in the body in which the utilization of glucose for energy is suppressed. These conditions will reduce brain inflammation.

Improves Health in Women With PCOS

Polycystic ovarian syndrome is a endocrine disorder which affects many women. It prevents them from having children, can cause a lot of pain and dysfunction within the body because the hormones are not in balance. A diet that is high in carbohydrates can be devastating for the health of a women with PCOS.

In a pilot study investigating the impact of a ketogenic diet on PCOS over a twenty four week period, it was discovered that the ketogenic diet increased weight loss, improved hormone regulation, improved luteinizing hormone (LH)/follicle-stimulating hormone (FSH) ratios and it improved the fasting insulin levels in women with PCOS.

The study concluded that further research is necessary to determine if the positive results are due to weight loss or a result of the ketogenic diet. It seems to me that the ketogenic diet most likely triggered some of that weight loss and therefore, it isn’t too much of a stretch to conclude that the ketogenic diet has a positive effect on PCOS.


The ketogenic diet is a healing diet. It helps to reduce inflammation and it aiding people in shedding excess body fat. The ketogenic diet is helping people with epilepsy to prevent painful and devastating seizures. The studies have not found a significant degree of side effects from the ketogenic diet. Therefore, it is a fine to conclude that doing a ketogenic diet will be relatively safe and even improve your health over time.

The concern that many people have about the ketogenic diet lies in the large percentage of fats that are included in the diet. The overall message that the food and drug administration has sent to us is that eating fat creates fat. However, the research that was used to come to that conclusion is not very reliable. It was an epidemiological study. There are many variables that could be causing the results that may not have been considered.

Based on recent research, anecdotal evidence from people who are on the ketogenic diets and reporting excellent health from them, and my own experience with the ketogenic diet, I would have to say that ketogenic diets are safe and effective. The challenge with the ketogenic diet for treating epilepsy is compliance with the diet. Many people are not very disciplined when it comes to food. Therefore, sticking with a ketogenic diet can become frustrating and often individuals will give up. The ketogenic diet can now be implemented with a lot of variety. Many ketogenic cookbooks are available as resources for people who are following a ketogenic diet. This free ketogenic cookbook offers those who are interested in doing the diet with a wide variety of recipes to choose from.





5 thoughts on “Are Ketogenic Diets Safe?”

  1. Hi Melinda,

    Thank you so much for writing this article. Keto is all the craze these days, and I can’t tell one diet from the other. Your article makes it so much easier to understand. Also, my family has a history of polycystic ovarian syndrome. My aunt didn’t have a child until she was in her mid-forties. It’s good to know that the ketogenic diet is helping so many people with this disease.

  2. Hi Melinda,
    Thank you so much for writing this article. Keto is all the craze these days, and I can’t tell one diet from the other. Your article makes it so much easier to understand. Also, my family has a history of polycystic ovarian syndrome. My aunt didn’t have a child until she was in her mid-forties. It’s good to know that the ketogenic diet is helping so many people.

  3. Ketogenic diet is becoming very popular among celebrities in my native homeland and because many people look highly to them, they are left wondering how this is done and how safe and effective it really is.

    Anyway, the first time I heard about this, it got me thinking how on earth does consuming fats help you loose weight. So thank you for the assurance that ketogenic diet is safe and effective not only in helping obese people get back in shape but also in treating epileptic patients.

    By the way, since you have tried keto diet yourself, do you have any tips or advice on how to prepare before diving into the diet especially for people who are used to eating carbohydrates.

  4. So interesting! I have a few friends that struggle with PCOS so I will definitely pass this along!
    I know my body could us a serious carb detox as well. Ugh… would be good for me to try as well.

    Thanks for the info!


  5. I have been meaning to research the keto diet for awhile now! I am a nurse and until now, I felt strongly that the keto diet should be limited to seizure patients with a doctor’s order. It seems that other people may be able to benefit, too! Thanks for including the studies on PCOS and obese people.

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